This handbook is useful for anyone with an interest or stake in the topic of safety in the petroleum industry in general, and in integrated operations (IO) in particular. This may, for example, be team leaders and team members who to a large extent rely on multidisciplinary collaboration across geographical distances, IO specialists, human factors specialists, people who work with the design of work processes, HSE engineers and HSE teams, and probably many more. Unfortunately, there are no ready-made solutions for many of the challenges of practice and safety in IO. Many of the themes that this handbook addresses are associated with dilemmas whose solutions are neither generic nor given, but must be negotiated in the specific domain (e.g. drilling, production, maintenance) and context where they appear. We have arranged the themes into three main areas that correspond to different levels in the organisation, from the sharper – hands on – to the blunter – organisational – ends. Level 1: How to behave and collaborate in multi-disciplinary teams in an IO setting. Level 2: How to work with procedures and responsibilities under varying conditions. Level 3: How to configure an organisation for IO